How is the INFUSEĀ® Bone Graft/LT-CAGEĀ® Device made?michelson=yep
The INFUSE® Bone Graft/LT-CAGE® Device contains recombinant human bone morphogenetic protein (rhBMP-2), the genetically engineered version of a naturally occurring protein that is capable of initiating bone growth, or bone regeneration, in specific, targeted areas in the spine. The genetic code for this protein is used to create large, pure quantities of the protein that can be used for fusion.
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The human gene for the the INFUSE® Bone Graft/LT-CAGE® Device bone forming protein is placed into cells that mass produce it. The protein is thoroughly checked for purity and packaged along with the carrier sponges in a sterile container for surgeon use.
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The INFUSE® Bone Graft/LT-CAGE® Device is manufactured by making cells that produce the protein in large quantities and growing the cells in special cultures. The process involves advanced techniques in molecular biology and genetics.
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The INFUSE® Bone Graft/LT-CAGE® Device contains a commercially available protein that has been purified to specifically generate bone in the immediate area that it is placed. The actual history is that 30 years ago scientists discovered that certain proteins were present in fracture/ bone healing. Scientists purified those proteins and found a number of bone morphogenetic proteins, meaning proteins that will change cells into bone producing cells. Once they identified a number of proteins, they identified the ones that worked best. Many researchers spent years and years purifying these to the point where they could reliably produce bones in humans. Then they used the current technology to take the protein and manufacture that in a commercial sense so that you have the product available today that we know as INFUSE Bone Graft.
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The INFUSE® Bone Graft/LT-CAGE® Device contains a protein made by a genetically modified cell in the lab that produces a substance, which is equal to the one that your body would normally produce after an incident that requires repair of bone tissue. This liquid protein used in combination with a sponge that prevents the protein from being absorbed rapidly by the bone tissue and excreted out of the body.
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The INFUSE® Bone Graft/LT-CAGE® Device contains morphogenetic protein. Through a special process the company can produce large quantities of this protein by using rapidly dividing cells to produce the protein.
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INFUSE® Bone Graft/LT-CAGE® Device contains a liquid morphogenetic protein, manufactured and placed inside of live cells, where it can rapidly multiply.
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The active agent in the INFUSE® Bone Graft/LT-CAGE® Device component is rhBMP-2. It is produced by a genetically engineered Chinese hamster ovary cell line. The rhBMP-2 is placed in a collagen gel and placed inside the fusion cage devices and then implanted into the body.
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The INFUSE® Bone Graft/LT-CAGE® Device is made from a human recombinant process where the protein is synthesized in cells. Then it is purified into the form that is used in patients.
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The genetic code for the special protein, called Bone Morphogenetic Protein, is placed into cells that generate large quantities of this protein. The protein is then purified and packaged at just the right dose to instruct your body to make bone.
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Important Safety Information
The commentary above recounts the experiences of these physicians. Medtronic invited them to share their stories candidly. Keep in mind that results vary; not every patient's response is the same. Talk with your doctor to learn more about any products that are mentioned above.
It is important that you discuss the potential risks, complications and benefits of spinal surgery with your doctor prior to receiving treatment, and that you rely on your doctor's judgment. Only your doctor can determine whether you are a suitable candidate for this treatment.
